Fibrinogen (Fibrogen)

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What is fibrinogen?

Fibrinogen is one of the 13 coagulation factors responsible for essential blood clotting.
It is a protein made in the liver, and it circulates in the blood of all vertebrates. When you injure yourself and start to bleed, thrombin converts fibrinogen into fibrin. Fibrin then turns into a blood clot to stop the bleeding and to heal wounds.

Thrombosis is a condition that may be caused as a result of low fibrinogen levels. This condition causes blood clots to form inside the blood vessels. This is dangerous as the blood flow is then blocked. This can lead to liver disease, heart attack, and stroke.

Testing

A fibrinogen activity test may be ordered to determine the cause of abnormal or prolonged bleeding. Other things to look out for include:

  • excessive bruising
  • excessive bleeding from the gums
  • frequent nosebleeds
  • blood in the urine or stool
  • poor wound healing

Tests may also be ordered if you have [1]:

  • abnormal results from a prothrombin time test or partial thromboplastin time test
  • symptoms of disseminated intravascular coagulation, which is a condition in which small clots form throughout the body
  • signs of an abnormal breakdown of fibrinogen (fibrinolysis)
  • a possible acquired or inherited factor deficiency that affects how your blood clots
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